CEACR 2020, 2(1), 58; doi: 10.35995/ceacr2010058
Challenges in Growth Hormone Therapy for Prader–Willi Syndrome
1 Department of Endocrinology, “Sfanta Maria” Clinic, 040674 Bucharest, Romania
2 Department of Endocrinology and Diabetes, “Elias” Emergency Clinical Hospital, Bucharest, Romania;
3 Department of Endocrinology, “Carol Davila” University of Medicine, Bucharest, Romania
* Corresponding author:
* Author to whom correspondence should be addressed.
(this article belongs to the Special Issue ENDOPED International Congress 2020)
Received: 26 Oct 2020 / Revised: 13 Nov 2020 / Accepted: 14 Nov 2020 / Published: 17 Nov 2020
Prader-Willi syndrome (PWS) is the most common syndromic cause of life-threatening obesity, scoliosis and obstructive sleep apnea (OSA) being the major concerns for these patients. We report the case of a five year-old girl with PWS admitted for growth hormone therapy. Initially she had medium-severe OSA that required tonisllectomy and severe scoliosis. At six months follow-up after intitation of therapy, she had a good response with better height and body fat index, OSA improvement, but progression of the scoliosis severity. With this case report we underline that, while growth hormone therapy in PWS patients is efficient and not directly related to scoliosis and OSA exacerbation, careful monitoring during therapy is recommended.
Keywords: growth hormone therapy; Prader–Willi Syndrome; chromosomal region 15q11-13
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Nicolaescu, D.I.; Albu, A.I. Challenges in Growth Hormone Therapy for Prader–Willi Syndrome. CEACR 2020, 2, 58.
Nicolaescu DI, Albu AI. Challenges in Growth Hormone Therapy for Prader–Willi Syndrome. Central European Annals of Clinical Research. 2020; 2(1):58.
Nicolaescu, Delia I.; Albu, Alice I. 2020. "Challenges in Growth Hormone Therapy for Prader–Willi Syndrome." CEACR 2, no. 1: 58.