%0 Journal Article
%A Nicolaescu, Delia I. Nicolaescu
%A Albu, Alice I. Albu
%D 2020
%J Central European Annals of Clinical Research

%@ 2668-7305

%V 2
%N 1
%P 58

%T Challenges in Growth Hormone Therapy for Prader–Willi Syndrome
%M doi:10.35995/ceacr2010058
%U https://ceacr.archive.jams.pub/article/2/1/96
%X Prader-Willi syndrome (PWS) is the most common syndromic cause of life-threatening obesity, scoliosis and obstructive sleep apnea (OSA) being the major concerns for these patients. We report the case of a five year-old girl with PWS admitted for growth hormone therapy. Initially she had medium-severe OSA that required tonisllectomy and severe scoliosis. At six months follow-up after intitation of therapy, she had a good response with better height and body fat index, OSA improvement, but progression of the scoliosis severity. With this case report we underline that, while growth hormone therapy in PWS patients is efficient and not directly related to scoliosis and OSA exacerbation, careful monitoring during therapy is recommended.